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Panobinostat phase 1 trial provides limited advance in HDAC inhibitor pipeline

The first clinical trial of Panobinostat by the Department of Infectious Diseases and Department of Immunology at Aarhus University Hospital, Denmark marks the next step in the development of the histone deactylase (HDAC) inhibitor group of latency reversal agents [1]. Thomas Rasmussen and colleagues describe results from this single-arm phase1/2 clinical trial of the second […]

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The use of convalescent plasma or serum

Over the summer, an international network of blood regulators developed a physician’s paper for regulators, and for anyone who might wish to become involved, outlining the reasons to consider antibodies derived from blood or convalescent plasma, or ultimately, hyperimmune globulins as a potential therapy in a filovirus outbreak. They provided an assessment of the previous

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Ebola vaccines in development

  The following table includes the leading candidates, however a number of these are not yet ready for a phase-1 trial but may be coming into trial over the next three to six months, and some are slightly longer term. Vaccine Manufacturers (developers): Vaccine details: Testing timeline: ChAd3-ZEBOV GlaxoSmithKline (National Institutes of Health (NIH) Chimpanzee

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Experimental therapies being evaluated to treat Ebola

Experimental therapies for Ebola include new compounds, as well as existing drugs approved for other purposes which demonstrate activity in laboratory models and which potentially could be repurposed. At least something is known about the approved drug’s safety profile, though the doses used for Ebola may not be the same. Each of the following potential

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WHO’s Comprehensive Plan to Rapidly Develop Therapeutics and Vaccines

Despite research into Ebola vaccines and therapeutics over the past decade, no product has been fully evaluated and approved for human use. This means that the only way to deal with this unprecedented outbreak has been to use the same basic public health and supportive care measures that were available in the past. Having an

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Is there a Black Market for Ebola Convalescent Blood Products?

“There have been reports about Ebola survivors selling their blood on the black market in the affected countries,” one audience member from Lagos, Nigeria said at a roundtable discussion on Ebola during the recent American Society of Tropical Medicine and Hygiene meeting in New Orleans in early November. “Is there any effort to regulate this?

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Coordination of new teams of Ebola responders a big challenge

“Coordination has been a routine failure in Ebola outbreak after Ebola outbreak,” Dr Armand Sprecher of MSF said during a roundtable discussion at the ASTMH conference in response to a question from a healthcare worker from Taiwan. She said her country would be sending a number of healthcare workers to the field soon and wanted

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