News

MSF doctor feels safe working in field fighting Ebola

Dr. Tim Jagatic of Médecins Sans Frontières spent March and April in Guinea when the Ebola outbreak was first recognized — and returned to West Africa to fight the disease in July. “When I went to West Africa the second time, people might have thought: 1) I’m masochistic and don’t have any sense of self-preservation, […]

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Ebola’s impact on West African countries health infrastructure

Ebola experts at the ASTMH conference in New Orleans concerned about the effect of Ebola on the health systems in Liberia, Guinea and Sierra Leone — as the Ebola response has drawn physicians and nurses away from the normal care system. “A lot of the health infrastructure has collapsed in these countries. For instance, maternal

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Operational aspects of the response: MSF in West Africa

“The number of things that need to go right for an outbreak to be controlled is significant — a lot of working pieces are interdependent,” said Dr Armand Sprecher of Médecins Sans Frontières at the 63rd Annual American Society of Tropical Medicine and Hygiene Conference this November in New Orleans. The health promoters and the

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Incidence of HIV dual infections in US men who have sex with men

  A new study published in the Journal of Infectious Diseases confirms that HIV dual infection and HIV reinfection are common. Researchers at University of California in San Diego and colleagues used new sequencing technology and phylogenetic analyses to determine the incidence and prevalence of dual infection by more than one strain of HIV in

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Have HDAC inhibitors fallen from grace?

Two recent papers present conflicting data on the efficacy of histone deacteylase (HDAC) inhibitors, the leading class of latency reversing agents (LRAs). Replication-competent integrated HIV provirus is able to form a persist reservoir in cellular compartments such as resting memory CD4 T cells by remaining in a long-term latent state that is highly stable.  Activation

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HIV reservoir: CD4 T stem cells may facilitate long-term persistence

A report in Nature Medicine is important for suggesting that a recently discovered and little understood subset of CD4 T cells are a long-term hiding place for the HIV reservoir. Maria Buzon and colleagues at the Massachusetts General Hospital and Massachusetts Institute of Technology, in Boston, describe their analysis of the HIV reservoir in different

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The critical role of the emerging middle-income countries in eliminating TB

Tuberculosis (TB) is largely under control in the industrialised countries of the ‘Global North’, which means that most of the effort to eliminate TB will fall on the shoulders of those emerging middle-income countries where TB is still an epidemic. HOW CAN BRICS PROMOTE RESEARCH TO END TB? In January this year (2013), the health

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Boston bone marrow patients not cured – viral rebounds reported at Viral Persistence During Therapy conference, Miami, FL

The Boston Globe this morning reports:- HIV virus returns after cure hope rose 2 Boston patients had transplants of marrow, halted powerful drugs   This story is being picked up by multiple news outlets now, including the NY Times and NPR. The findings were reported by Dr Timothy Henrich of the Brigham and Women’s Hospital in

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Professor Gilla Kaplan: TB research needs to address key assumptions about TB that could be mistaken

Changing the perspective of research to end TB: a global venture “Suboptimal tools to detect, treat or prevent TB necessitate development of new tools,” said Professor Gilla Kaplan, speaking at the Stop TB Symposium, that was held on October 30, 2013, a day before the 44th Union World Conference on Lung Health. Prof Kaplan is

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Dr Christian Leinhardt: Research in the post-2015 Global TB Strategy: Finding lessons in the past and models in the present

While the previous presenters at the Stop TB Symposium, held on October 30, 2013, just before the 44th Union World Conference on Lung Health in Paris,  focused on the new Global Strategy — and the new target of TB elimination by 2035 (see recent posts) — Dr Christian Leinhardt of WHO’s Global TB Programme set

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