Blog posts

Fatty liver disease found to be very common in both younger and older people living with HIV according to cohort study in diverse population

  [Lance Sherriff assisted in the transcription and compilation of this article.] Fatty liver disease (hepatic steatosis) was found to be very common among people living with HIV in a cross-sectional study involving 160 people on antiretroviral treatment, according to data presented at the 9th International HIV and Aging Workshop last week in New York […]

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Even newer NRTIs (anti-HIV drugs) found to cause mitochondrial damage in muscle

[Lance Sherriff assisted in the transcription and compilation of this article.] Mitochondria (the small organelles in cells that are critical for energy production) within the muscle fibers of antiretroviral-treated people living with HIV may be significantly damaged, according to a study presented last week in New York at the HIV and Aging Workshop by researchers

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Linking people living with HIV and aging issues to appropriate care: Efforts from New York City’s Department of Health, ACT UP and NATAP

  Many of the aging people living with HIV suffering the most may not be able to defend themselves.  Key points: An ACT UP working group is starting to compile a list of HIV care facilities with experience treating long-term survivors and people living with HIV over the age of 50 who are experiencing aging-related

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The high risk of frailty in middle-aged people living with HIV

  Frailty, the condition of depleted energy and physiological decline that is often seen in the elderly and that makes them less capable of recovering from illness, accidents and the stresses of life, has been reported to be significantly more common in people living with HIV — even in middle-aged people on antiretroviral treatment (ART)

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AIDS 2018: Disappointing results from vedolizumab study re durable suppression off antiretroviral treatment strategy

  Last week, I retweeted a press release from the NIH about a presentation that Tony Fauci was going to make at the AIDS Conference, which featured the lead quote “Durable control of HIV infection in the absence of antiretroviral therapy is a feasible concept that deserves vigorous pursuit.” This was referring to the ‘cure’

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The use of convalescent plasma or serum

Over the summer, an international network of blood regulators developed a physician’s paper for regulators, and for anyone who might wish to become involved, outlining the reasons to consider antibodies derived from blood or convalescent plasma, or ultimately, hyperimmune globulins as a potential therapy in a filovirus outbreak. They provided an assessment of the previous

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Ebola vaccines in development

  The following table includes the leading candidates, however a number of these are not yet ready for a phase-1 trial but may be coming into trial over the next three to six months, and some are slightly longer term. Vaccine Manufacturers (developers): Vaccine details: Testing timeline: ChAd3-ZEBOV GlaxoSmithKline (National Institutes of Health (NIH) Chimpanzee

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Experimental therapies being evaluated to treat Ebola

Experimental therapies for Ebola include new compounds, as well as existing drugs approved for other purposes which demonstrate activity in laboratory models and which potentially could be repurposed. At least something is known about the approved drug’s safety profile, though the doses used for Ebola may not be the same. Each of the following potential

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