Results of the United Kingdom PROUD study were published in the September 9th issue of the Lancet, following their earlier presentation at the Conference on Retroviruses and Opportunistic Infections 2015, in Seattle [1]. As reported at CROI, pre-exposure prophylaxis (PrEP) dramatically reduces the risk of HIV infection in gay men and transgender females by …
The first clinical trial of Panobinostat by the Department of Infectious Diseases and Department of Immunology at Aarhus University Hospital, Denmark marks the next step in the development of the histone deactylase (HDAC) inhibitor group of latency reversal agents [1]. Thomas Rasmussen and colleagues describe results from this single-arm phase1/2 clinical trial of the second …
Panobinostat phase 1 trial provides limited advance in HDAC inhibitor pipeline Read More »
A new study published in the Journal of Infectious Diseases confirms that HIV dual infection and HIV reinfection are common. Researchers at University of California in San Diego and colleagues used new sequencing technology and phylogenetic analyses to determine the incidence and prevalence of dual infection by more than one strain of HIV in …
Incidence of HIV dual infections in US men who have sex with men Read More »
Two recent papers present conflicting data on the efficacy of histone deacteylase (HDAC) inhibitors, the leading class of latency reversing agents (LRAs). Replication-competent integrated HIV provirus is able to form a persist reservoir in cellular compartments such as resting memory CD4 T cells by remaining in a long-term latent state that is highly stable. Activation …
A report in Nature Medicine is important for suggesting that a recently discovered and little understood subset of CD4 T cells are a long-term hiding place for the HIV reservoir. Maria Buzon and colleagues at the Massachusetts General Hospital and Massachusetts Institute of Technology, in Boston, describe their analysis of the HIV reservoir in different …
HIV reservoir: CD4 T stem cells may facilitate long-term persistence Read More »
An alarming increase in the incidence of both HIV-infection and other sexually transmitted infections (STIs) has been occurring amongst men who have sex with men (MSM) in England over the last two years. A number of news reports highlight an alarming increase in the incidence of gonorrhoea, chlamydia and syphilis among MSM, particularly in …
London’s HIV crisis: A storm seeded in the noughties? Read More »
The Boston Globe this morning reports:- HIV virus returns after cure hope rose 2 Boston patients had transplants of marrow, halted powerful drugs This story is being picked up by multiple news outlets now, including the NY Times and NPR. The findings were reported by Dr Timothy Henrich of the Brigham and Women’s Hospital in …
On September 11th 2013, news media outlet WBNS-10TV in Columbus, Ohio, carried a story about a local man who has been charged with “Allegedly Not Notifying Partner of HIV Status”. While the story makes its way round other news outlets, there has been no court hearing as yet, no conviction has been made and all …
Criminalization of People with HIV: Reaction to a breaking story in Ohio Read More »
Gareth is faculty at the Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA and has extensive experience working in the field of HIV immunology over the last 15 years. He received his bachelor’s degree in Immunology at University College London and his Ph.D. in Immunology at Imperial College of Science, Technology and Medicine, …